- What is included in the GLASS Data Resource?
The GLASS Data Resource consists primarily of standardized somatic variants (somatic single-nucleotide variants and DNA copy number segments) and clinical annotation of a cohort of adult patients with a glioma. On a subset of cases, gene expression profiles and/or DNA methylation profiles are available. All profiles were contributed by GLASS members. As a result, the GLASS Data Resource is a heterogeneous dataset. Please take a moment to familiarize yourself with the Resource per the descriptions on the Synapse portal: https://www.synapse.org/glass.
- What processing pipelines and tools were used to establish the GLASS Data Resource?
All pipelines and descriptions are available on the Verhaak lab Github page.
- Can the raw sequencing data be analyzed?
Not at this time. The GLASS Data Resource was compiled from datasets contributed by GLASS members world wide. This means there is a number of jurisdictions that need to be considered for different subsets of the Data Resource. The GLASS Consortium continues to explore options for making analysis of the raw data possible. Suggestions are always welcome. Contact details on the Contact page.
- How often will the GLASS Data Resource be updated and when is the next release?
Future releases of the GLASS Data Resource are in development. While we do not have an anticipated date of release at this time, we are working towards a bi-annual release schedule. Benefits of becoming a GLASS member include early access to the Data Resource. Further information on becoming a member can be found on the Membership page.
- What preprocessing pipelines were used to create the GLASS Data Resource?
For information on processing pipelines, please review the information on GLASS Synapse Portal, https://www.synapse.org/glass.