The current GLASS Data Resource was publicly released on September 30, 2025, and is available via http://www.synapse.org/glass. Details on how the Data Resource was compiled and what it includes are available on the Synapse portal, as well as terms of use.
FAQ#
- What is included in the GLASS Data Resource?
The GLASS Data Resource consists primarily of standardized somatic variants (somatic single-nucleotide variants and DNA copy number segments) and clinical annotation of a cohort of adult patients with a glioma. On a subset of cases, gene expression profiles and/or DNA methylation profiles are available. All profiles were contributed by GLASS members. As a result, the GLASS Data Resource is a heterogeneous dataset. Please take a moment to familiarize yourself with the Resource per the descriptions on the Synapse portal: https://www.synapse.org/glass.
- What processing pipelines and tools were used to establish the GLASS Data Resource?
All pipelines and descriptions are available on the Verhaak lab Github page (10/10/2026 update: https://github.com/verhaaklab/glass-idh).
- Can the raw sequencing data be analyzed?
The GLASS Data Resource was compiled from datasets contributed by GLASS members world wide. This means there is a number of jurisdictions that need to be considered for different subsets of the Data Resource which greatly complicates raw data access. The GLASS Consortium continues to explore options for making analysis of the raw data possible. Suggestions are always welcome. Contact details on the Contact page.
- How often will the GLASS Data Resource be updated and when is the next release?
GLASS Data Resource releases are not published on a set schedule. Check back regularly here or at www.synapse.org/glass to find the latest version.
- What preprocessing pipelines were used to create the GLASS Data Resource?
For information on processing pipelines, please review the information on GLASS Synapse Portal, https://www.synapse.org/glass.